What is the risk associated with prolonged use of fluoroquinolones?

The risk associated with prolonged use of fluoroquinolones includes tendon rupture. Fluoroquinolones can lead to serious side effects such as tendon damage and rupture, particularly of the Achilles tendon. This risk is increased in certain populations, including older adults, those taking corticosteroids, and individuals with kidney problems.

Tendinopathy can manifest as pain, swelling, and increased risk of tendon rupture, which may occur spontaneously or with minimal exertion. This potential adverse effect is particularly concerning given that some patients may not be aware of the risk, and the consequences of a tendon rupture can significantly impact mobility and quality of life.

In contrast, while other options may involve relevant risks in different contexts, they are not commonly associated specifically with fluoroquinolone use. Thus, the focus on tendon injury directly addresses a well-documented risk linked to prolonged use of this class of antibiotics. Understanding these side effects is crucial for clinicians when deciding on appropriate antimicrobial therapy and monitoring their patients.