What is a common side effect of isoniazid therapy?

Isoniazid is a medication primarily used in the treatment and prevention of tuberculosis. A common side effect associated with isoniazid therapy is peripheral neuropathy. This condition occurs due to the drug's mechanism of action, which involves the inhibition of vitamin B6 (pyridoxine) metabolism. Vitamin B6 is essential for proper nerve function, and its depletion can lead to symptoms such as tingling, numbness, or pain in the extremities, which characterize peripheral neuropathy.

Preventative measures, such as administering vitamin B6 alongside isoniazid, are often recommended to mitigate the risk of developing this side effect. Understanding the association between isoniazid and peripheral neuropathy is crucial for healthcare professionals to monitor patients effectively and ensure optimal therapeutic outcomes while minimizing adverse effects.